In your tutorial groups, please conduct literature research on the above assigned class of anti-cancer drugs.
You should discuss on
-the mechanism of action of the drugs,
-the nature of the drug targets,
-in vitro & in vivo assays for drug action in preclinical animal models,
-preclinical development of biomarkers for prediction/diagnosis of safety,
-drug properties,
-efficacy & patient selection.
Proteasome as an Emerging Therapeutic Target in Cancer (2007)
http://www.ingentaconnect.com.libproxy1.nus.edu.sg/content/ben/cpd/2007/00000013/00000005/art00004
Proteasome inhibitors: antitumor effects and beyond (2007)
http://www.nature.com/leu/journal/v21/n1/full/2404444a.html
Proteasome Inhibitor Drugs on the Rise (2006)
http://cancerres.aacrjournals.org/cgi/content/full/66/16/7840
Highlights in experimental therapeutics (2006)
http://linkinghub.elsevier.com/retrieve/pii/S0304383506001662
Proteasome inhibition: a new approach for the treatment of malignancies (2005)
http://www.jle.com/fr/revues/medecine/bdc/e-docs/00/04/18/35/article.md?type=text.html
Proteasome Inhibition in the Treatment of Cancer
http://www.landesbioscience.com/journals/cc/article/richardsonCC4-2.pdf
Proteasome Inhibition As a Novel Therapeutic Target in Human Cancer (2005)
http://jco.ascopubs.org/cgi/content/full/23/3/630
Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy (2005)
http://www.cancerci.com/content/5/1/18
THE PROTEASOME AND PROTEASOME INHIBITORS IN CANCER THERAPY (2005)
doi:10.1146/annurev.pharmtox.46.120604.141300
The development of proteasome inhibitors as anticancer drugs.
http://linkinghub.elsevier.com/retrieve/pii/S1535610804001205
Proteasome Inhibitors for Cancer Therapy (2003)
http://www.suite101.com/article.cfm/new_cancer_treatments/102463/1
Cancer treatment information
http://www.oncolink.com/treatment/article.cfm?c=12&s=89&id=260
The Scientific Athlete 
Recent Comments